The Excel file slow to respond is a very irritating issue and there are many reasons behind the slowness or crashing, freezing or not responding issue in Excel.
To fix the issue update the Graphic card drivers, disable the hardware acceleration, change default Printer, remove unwanted formulas and optimize your workbook.
These are some of the tricks the help you to fix slow to respond issue in Excel. Apart from that, there are many other tricks as well that works for you.
To know more visit: http://www.repairmsexcel.com/blog/resolve-excel-slow-respond-issue